THIRTY YEARS AGO
Do you remember the summer of ’81? Right now, chances are some of you may be conjuring up fun and pleasant memories to share.

Doctors in New York City, Los Angeles, and San Francisco at that time, however, would have some very different memories. Strange clusters of cases of pneumonia and cancer were arising there in gay men – diseases typically only seen before in immunosuppressed patients. Diseases that were killing these patients.

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FAST FORWARD TO TODAY
Thirty years on, however, and we now know that these were not primary conditions in their own right, but were secondary, in association with the disease that we now know as AIDS.

Thankfully a diagnosis of HIV infection today no longer has to represent the kind of death sentence that it did 30 years ago, but millions of people do continue to suffer around the world. Despite decades of promises of a vaccine, this sadly still remains but a promise.

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THE GENDER EPIDEMIC
We now also know that AIDS is not just a disease of gay men. In contrast today, women account for almost half of all people with HIV/AIDS. Tragically, this condition represents the leading cause of death in women or reproductive age.

HIV contraction thus clearly poses very different risks and consequences for girls and boys around the globe. Frighteningly, there is an escalating risk of HIV infection/AIDS in young women and girls, with half of all new infections arising in the 15-24 year old age group. And in sub-Saharan Africa, for example, young females in this age group are twice as likely to have HIV/AIDS than their male counterparts.

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WHY THE ESCALATION IN YOUNG GIRLS?
The feminization of the epidemic highlights the gender inequalities at the root of this trend, with socioeconomic issues, as well as biological factors coming into play.

Socioeconomic Issues:

  • Young girls may be forced into commercial sex
  • Power imbalances in some populations leave girls subjected to non-consensual sex
  • Young girls often have sex with older males who are more likely to have HIV/AIDS
  • Girls have less access to general life skills-based education and resources, thus leaving them more vulnerable to infection
  • Girls tend to know very little about all matters of sex education, including how to protect themselves against STDs, increasing their risk of infection

Biological Factor

  • The immature genital tract of a young girl is more susceptible to damage during sexual activity, increasing the risk of HIV transmission

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WHAT CAN BE DONE?
Women have inevitably now become the face of HIV/AIDS across the world, constituting an increasing proportion of adults (15-49 years of age) living with the condition. To help protect women across the globe, and reduce the unique effect that the AIDS epidemic has on them we must:

  • Improve women’s general, sexual and reproductive health education
  • Promote and protect the human rights of women
  • Introduce better post-exposure treatment

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WHAT MOVES ARE UNDERWAY TO IMPROVE THE SITUATION?
UNAIDS  for example has various strategy goals in place for 2015, which include addressing HIV-specific needs of women and girls, as well as a zero tolerance for gender-based violence.

The World Health Organization (WHO) is in agreement, and similarly aims “to achieve universal access to HIV prevention, diagnosis, treatment and care interventions for all in need”, through their Global Health Sector Strategy on HIV/AIDS (2011-2015).

The WHO rightly calls on the world “to build on the collaboration, innovation and investment that have forged hard-won progress to date, establishing the foundation for success over the next five years.”

Read more about the Girl Effect, and see what you can do for the movement.

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Image Credit morgueFile

It’s no longer just a cat’s eyes that glow in the dark! Researchers at the Mayo Clinic have created luminescent, genetically modified cats in an effort to learn more about AIDS.

Feline immunodeficiency virus (FIV) causes feline AIDS, a condition in cats that produces almost identical symptoms to those of AIDS in people infected with human immunodeficiency virus (HIV). Despite the similarity of the viruses, however, it should be noted that people cannot become infected with FIV, and cats cannot be infected by HIV. The similarity of both viruses, however, allows FIV to be used as a model for studying AIDS.
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In this most recent study, the Mayo group inserted two genes into the cats’ eggs prior to fertilization with sperm:

  • An FIV-resistance gene that makes a protein called restriction factor
  • A jellyfish gene to produce GFP, a protein that causes the modified cells to glow green

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Restriction Factor Proteins
Restriction factor proteins usually help the body to block viral infections. But in the case of HIV and FIV infections, these viruses have developed ways to evade attack by the proteins. The rhesus macaque version of restriction factor, however, is able to fight the viruses, so this monkey provided the source of restriction factor.
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Gamete-Targeted Lentiviral Transgenesis
Since cross-breeding of cats and monkeys is not an option, this genetic engineering process was used to introduce the monkey genetic material into cats. Insertion of the monkey restriction factor into the cats was so successful that almost all kittens produced from the genetically modified eggs had the genes for the protective restriction factor protein.

This protein was found all over the body, being tracked by virtue of its green glow, courtesy of the jellyfish gene that had also been introduced at the same time. The GFP protein produced by this gene acts as a marker – it allows the restriction factor proteins to be easily located in the body because it causes them to glow green.

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So What Was The Big Deal About This?
Cells that were subsequently taken out of the cats were found to be resistant to FIV infection when tested.

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The Future?
Although the research is still in its early stages, it certainly shows some exciting potential that could benefit both HIV-infected people, and FIV-infected cats. The Mayo team aims to further study these cats as a means to develop new therapies for people and cats infected with these viruses.

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Photo Credit BBC