Were you one of the 50% of Americans who set up a New Year’s resolution last month as you rang out the old, and rang in the new? If so, I’m sure it’s no surprise to you to learn that although some people manage to stick with their goals, the majority, however, give up.

“What a mistake – the whole idea around New Year’s resolutions. People aren’t picking specific behaviors, they’re picking abstractions,” says Stanford University Professor, BJ Fogg.

Professor Fogg explains that people simply don’t do well when it comes to the vague aspirations that comprise most resolutions. He feels that abstract goals don’t work unless they are tied to specific behaviors, because they can be too difficult for the brain to focus on. He says that in order to retain new behavior, it needs to be instinctual – the more you have to remember to do something, the better the chances are that you’ll talk yourself out of it.

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Why Our Brain Has Trouble Handling New Year’s Resolutions 

We all know that willpower is the magic ingredient to help us stick to our resolutions. The cells in the brain that control willpower are found just behind the forehead, in the prefrontal cortex – the region that is also responsible for managing short-term memory, helping us stay focused, and solving abstract tasks. 

But the problem with the good old New Year’s resolution is that it typically requires a huge amount of willpower to carry it out – so much that our brain just can’t cope. Professor Baba Shiv at Stanford University demonstrated this, using 2 groups of undergraduate students. He gave one group a two-digit number to remember, and the other a seven-digit number to remember. Following a short walk, the two groups were offered a choice of two snacks: a slice of chocolate cake or a bowl of fruit. Surprisingly, the students with 7-digit numbers to remember were twice as likely to pick the slice of chocolate compared to the students with the 2-digit numbers. 

Why does this happen? “Those extra numbers took up valuable space in the brain—they were a “cognitive load” – making it that much harder to resist a decadent dessert”, says Shiv. 

Consequently, your prefrontal cortex needs to manage willpower in much the same way as a muscle needs to be trained. Making a decision at the start of the New Year to tax your prefrontal cortex with something like a resolution to stop smoking or to join a gym for the first time, is likened to trying to lift a 300lb barbell without any previous training.

However, making a new behavior “instinctual” – the crucial aspect for keeping it going – will better help you achieve any new habit. Since this is missing in 90% of all New Year’s resolutions, it makes them so likely to fail.

Fogg describes how the key is to make any goal a habit first. And, most importantly, to make it a tiny one. How might this translate to some of the most common New Year’s resolutions? Well, instead of making a vague aspiration to stop smoking, first resolve to merely stop smoking that one cigarette you have every morning after breakfast. And instead of simply declaring how you’re going to only eat healthy food, start by substituting that daily morning pastry for a banana. The chances of success will be 50% higher if you can break down your resolution into a small habit, rather than leaving it open and vague.

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Positive Reinforcement

Fogg also believes in the power of positive reinforcement by rewarding yourself immediately after performing your new habit. For example, if flossing your teeth is your new resolution, start by flossing just one tooth, instead of trying to floss them all. And then reward yourself! “You declare victory. Like, “I am so awesome, I just flossed one tooth.” And I know it sounds ridiculous. But I believe that when you reinforce yourself like that, your brain will say yeah, awesome, let’s do that,” says Fogg.

This concept of behavioral triggers and rewards likely sounds familiar to those of you with pets.  According to Fogg, “If you really took the techniques for training dogs and applied them to yourself, you would have much better success. Now, I’m sure people are upset with me for saying that because people want to think we’re different from other animals. When it comes to behavior, we’re a lot more alike than people want to believe.”

So, if you’re anticipating a hard time sticking with your resolution this year, hopefully you can now take some comfort in knowing that, despite popular opinion, a strong willpower is not something we’re born with. Self-control is not simply a character issue. Although most people assume that we would follow-through on our resolutions if we had a bit more discipline, this is not the case.

“Research suggests that willpower itself is inherently limited, and that our January promises fail in large part because the brain wasn’t built for success,” says Jonah Lehrer, author of “How We Decide” and “Proust Was a Neuroscientist.”

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Image credit Stuart Miles @FreeDigitalPhotos

Ever wondered how scientists declare their love? Well, check out some data that was shared in the British newspaper, “The Guardian”….

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Even back in history, scientists worked hard to pursue their love interests: 

In a classic piece of work by Jacques-Louis David, an influential French neoclassical painter, Antoine-Laurent de Lavoisier, the “father of modern chemistry” was shown gazing lovingly at his wife and co-worker, Marie-Anne, over a table that was laden, not with candles, but with the symbols of a shared love of chemistry. 

Then there was the 18th century German professor, Georg Matthias Bose, who developed early theories of electricity. He would ask a lady to stand on an insulated stool whilst her body was charged with electricity by a hidden operator. He would then introduce an unsuspecting gentleman to kiss her. Not surprisingly, sparks would fly.

And how about the 19th century American, Joseph Henry, a professor and pioneer of the first electromagnet?  Whilst studying inductance, he constructed a magnetic relay that connected his lab at Princeton University to his home. Henry used this device to send waves of love to his wife Harriet, and, more importantly, to send her his lunch order. This pioneering work eventually led to the invention of the telegraph.

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Let’s fast forward to the 21st century to see if the age of chivalry is dead:

Researcher in nanotechnology at Purdue University, Sahil M. Bansal, admits that he uses his hi-tech skills to make gifts for love interests. In his production of nanoscale circuits, tiny gold patterns are dabbed onto silicon wafers. He puts his leftover wafers to good use, though, by inscribing them in gold with nanoscale poetry. Apparently it’s never failed him.

And, naturally, no self-respecting report on romance would be complete without some quotes from the Twitterverse:

A lecturer in organic chemistry at the University of East Anglia, @S_J_Lancaster, tweeted: “Valentine, I could never Bohr of you”. And later: “Say silsesquioxane again, the way I like it.”

Then there was @Sci_ents of the University of Hull, who announced: “I said I liked her bosons and then she lepton me”.

And finally, chemistry student, @simplecoffee, of the University of Delhi, declared: “You drown me in dopamine. May I be your alpha carbon?”

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So, the moral of this story? You should definitely think carefully before taking advice on romance from a scientist….

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Image credit imelenchon  @morgueFile

 

 

 

 

 

Dropped foods with high salt or sugar content may be safer to eat than other foods, study reports.
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This finding has important implications for followers of the “3-Second Rule”, and was reported by researchers at Manchester Metropolitan University in England, on behalf of Vileda, a household products company.

Are you a proponent of the 5-second rule (or whatever time limit you choose to use)? There seem to be any number of variations on this rule, with the time limit often being modified based on how long it actually takes a person to retrieve their dropped food before the dog gets to it!

Call it what you like – superstition or conventional wisdom – this rule has certainly received some scholarly attention over the years, including this most recent study.

The researchers tested a variety of foods that are eaten commonly, and that contain different water activity levels – a major factor in determining whether food items will allow bacterial growth in just a few seconds.

Ham, cooked pasta, bread with jam, a plain cookie, and dried fruit were all dropped on the floor and then left for intervals of 3, 5, and 10 seconds. The foods were then evaluated to determine whether harmful bacteria found on the floor were then found on the dropped food.

They found that the level of water, salt, and sugar in a food type influenced how much bacteria it collected. Due to their low water content, cookies appeared to do best, and were relatively safe to eat after being on the floor for 3, 5, or 10 seconds. The salty ham and the sugary bread and jam seemed to do relatively well, showing little bacterial growth if they were removed from the floor within 3 seconds. But the cooked pasta and dried fruit showed growth of klebsiella after just 3 and 5 seconds respectively – a bacterial agent with the potential to cause a range of diseases such as urinary tract infection, pneumonia, and septicemia.

Overall this study showed that processed foods with their high sugar or salt content were less likely to allow harmful bacteria to survive on them, and may therefore present the least risk to health when eaten off the floor – maybe their only saving grace from a healthy eating standpoint!

But regardless of the results, it’s important to obviously remember that any dropped food becomes immediately contaminated, whatever its water, salt, and sugar content. So even though there may be degrees of contamination – when in doubt, throw it out!

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Update from our AMWA-New England Chapter

I was recently asked by the President of our local AMWA-New England Chapter to become an Executive Committee (EC) member. Naturally I was delighted and honored to be asked, and I accepted very graciously. Tonight was our summer EC meeting, and my first as a member.

We all met in Burlington, MA at a local Panera Bread there – apparently they used to have a ameeting room there where members could congregate, but this is no longer available. But it was still a great location for everyone – central for most members to get to, and I have to say I always love the food there. Plus they always have decent coffee too – and they keep tabs on the timing of when it was brewed, and refresh it regularly – always a bonus in my book!

It was great catching up with a bunch of folk who I know already from the New England Chapter, as well as meeting some others who I’ve not yet met. We had a full agenda for the evening, but managed to accomplish everything in decent time. And the plentiful supply of coffee was a great help!

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2012 AMWA Annual Conference

If you’re thinking of going to the AMWA Annual Conference this year, don’t forget to register in advance to take advantage of the lower fees and ensure that you secure a hotel room. The conference will be held in Sacramento, CA from Oct 4-6, at the Convention Center in the city.

I’m hosting a breakfast roundtable on Saturday on “How to Advance Your Medical Writer Career Through Blogging”, so I’m excited about being involved in that, as well as being able to catch some of the other great sessions on the schedule. 

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Not a Member of AMWA Yet?

If you’re starting out in medical writing, I’m going to send you my regular plug to join AMWA! Hopefully there will be a local chapter within reasonable commuting distance – if so, regular involvement in meetings will be really beneficial for you. And if you’re considering going to the annual conference, you’ll pay less for registration.

 

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Researchers find that pets may actually help to reduce allergies.

 

July 13th – children who grow up with a dog in the house may be less likely to develop allergies and respiratory infections later on in life, new research suggests.

Kei Fujimura, PhD, and colleagues, presented their findings on June 19th at the 112th General Meeting of the American Society for Microbiology in San Francisco.  

While previous studies have demonstrated that children with pets are less likely to develop asthma, a new study has shed some light on how this may occur – if results in mice apply to people. 

Earlier work by Dr. Fujimura and colleagues showed that pet-friendly homes have microbiomes that are much more diverse than pet-free homes, and that some of the bugs could be helpful bacteria, such as ones that help with digestion. 

As a follow-up, the researchers aimed to evaluate the link between house dust and respiratory syncytial virus (RSV), a common pathogen that infects children, making them more prone to developing childhood asthma. 

In their study, mice were divided into 3 groups. Mice in the first group were fed dust from homes with pets, and were subsequently exposed to respiratory syncytial virus (RSV). Mice in the second group were only infected with RSV, and those in the third group were uninfected. 

The animals fed the house dust did not show symptoms of the infection, such as airway swelling, and mucus production. The composition of their gut bacteria was also very different from that of mice who were not exposed to the dust. 

Early childhood is a critical time for development of protection against allergies and asthma, and it seems that exposure to pets can be beneficial. The researchers believe that early exposure to allergens can help the immune system to mature more quickly to protect against allergies and asthma. 

Now it remains to be determined which of the microbes are responsible for guarding against this infection – information which could be important for the development of therapies to protect against RSV and maybe decrease the risk of childhood asthma. 

The recent unveiling of the Human Microbiome Project will hopefully help to make this a reachable goal.

 

 

Image credit elemenoperica @morgueFile

 

 

We’re in the thick of conference season, so covering meetings is still very much on my mind. I recently shared some of the things I do before covering a medical conference, and thought I’d follow up by sharing some of the things I do when the conference rolls around.

This might be helpful to you if you’re preparing to cover your first conference.

 

 

  1. Check in: Sounds obvious, yes, but be prepared! You likely won’t need to use the same line to collect your badge as the conference attendees. Most of the time you just have to report directly to the Press Room at the meeting – usually located in a quieter location than the main area where the meeting is being held. Check on the conference website before you go – sometimes the “Press Information” link will provide details about checking in. If there are no specific instructions, simply ask where the Press Room is when you get to the meeting, and likely your badge will be ready and waiting for you. Obviously you don’t necessarily need to arrive at the conference venue until you’re needed there. So if your first presentation to cover isn’t until the afternoon of the first day, don’t feel the need to arrive when the meeting opens up in the morning –  unless you want to, of course.
  2. Settle in: I like to arrive at the meeting each day about an hour before the start of whatever I’m covering. Usually I’ve traveled in from somewhere – interstate driving and trains have been involved! So I like to sit around and gather my thoughts in the Press Room. Typically there are plenty of goodies to be had in there too – coffee, pastries, cookies, etc. So it’s always nice to grab a drink and a snack while I plan out my attack. This is a good time to check the building plan too, so you can figure out what rooms are located where – if your conference is a huge one at an even more huge venue, this can be really helpful, especially if you have to switch from room to room in between talks without too much time to spare. This is the time to double-check the times and locations of your presentations for the day.
  3. Get a good seat: When you’re covering an oral presentation, you’ll want to do whatever you can to get the best seat possible. Obviously if you are running between rooms with little time to spare, you might just have to settle for what you can get. But if time isn’t an issue, do try to plan ahead – this will make all the difference to your comfort (and hence coverage of the presentation), especially if it’s a longish talk. Arrive in advance of the session if you can – this might make it more likely that you’ll be able to grab one of the table seats. Sit close to the front, and along the aisle – especially if you want to take photos of the screen, grab the presenter at the end for questions, or make a quick exit to cover a parallel session in a different room. If you are recording the session, avoid rows closer to the front than the loudspeakers – the sound often ends up muffled.
  4. Plan ahead for the poster sessions: At the large conferences, poster sessions typically are constantly rotating, so you need to ensure that you don’t miss out on seeing the ones you’d planned to cover. Sometimes if you hit the poster boards as your particular session begins, some posters may not have been pinned up. But I admit that I usually still try to get there within the first 30 minutes of the session to get an early viewing of those that are ready. I like this time because it tends to be a bit quieter than when presenters are required to stand at their board. So you get a head start in catching some of the poster presentations that you want to cover, and allows some space for photographing them without too many other folk elbowing you. It also gives you a chance to scope out any extras that catch your eye – this can be useful if you have a last-minute emergency, say if someone doesn’t turn up for the meeting and your chosen poster isn’t presented after all. Having a stand-by can be helpful – and your editor will be happier with a replacement than one less story! 

 

Image Credit David Castillo Dominici @FreeDigitalPhotos

Are you someone with a sedentary job?

A recent study showed that breaking up long periods of sitting time by finding ways to move regularly, and increasing activity level, may have important implications for patients with diabetes, as well as reducing cardiovascular disease risk.

Although the study involved overweight individuals, this is obviously good advice for any of ud who might spend long periods of time each day working at a desk!

Read more about these findings in an article that I wrote for Be Sure To Test.

 

 

Image credit cohdra @morgueFile

If you’re fortunate enough to have a day off today, it’s because of the sacrifices made by our military servicemembers. 

We have a beautiful Memorial Day tribute in Boston right now. For the 2nd year running, a garden of flags blankets the ground in front of the Soldiers and Sailors Monument on Flagstaff Hill on the Common. 33,000 flags are currently planted, in honor of Massachusetts’ servicemembers who’ve died in conflicts dating back to the Civil War.

Breathtaking, to say the least.

Be sure to thank a servicemember today.

Physicians should be reminded of the potential for medication errors by pet-owning patients and veterinarians as a result of self-medication.

This was the message from a case reported in a clinical communication to the editor by Harmeet Singh Narula, MD, from the Department of Medicine, SUNY Stony Brook, NY, in this month’s American Journal of Medicine (published online, May 7, 2012).

A 33-year-old veterinarian with Hashimoto’s thyroiditis and hypothyroidism presented with mild anxiety, jitteriness, and insomnia.

Although the patient’s thyroid condition had been previously stable with levothyroxine replacement therapy, at the time of presentation, her thyroid hormone levels (serum total T4 and free thyroxine index) were discovered to be high.

Upon questioning by the physician, the patient admitted that she had run out of her levothyroxine prescription, and instead had switched to using a canine levothyroxine formulation. It was discovered that she had been taking a tablet dose of 0.5 mg daily, thinking that this was equivalent to the 50 µg daily dose that she had been originally prescribed, and was therefore taking 10 times the required dose.

The patient was instructed to stop taking the canine medication. Her thyroid function was restabilized, and she was warned to only take physician-prescribed medication in the future.

Hypothyroidism is a common condition in both people and dogs. However, the levothyroxine replacement dosages are much higher in dogs than in people, and the recommended starting dose is at least 25 times higher in dogs.

Levothyroxine also has a narrow therapeutic index, so mistakes in dosage can occur relatively easily due to prescription or dispensing errors.

Since veterinarians and pet owners have easy access to pet medications, physicians should recognize the possibility for such errors in these patients. Sudden unexpected changes in patient condition should be cues for physicians to enquire about any self-induced switches in medication.

 

Image credit FreeDigitalPhotos

A couple of months ago I received an email from a gentleman called Paul, from Georgia. He asked if I had any tips on getting into regulatory writing. Unfortunately I wasn’t able to be of much help to him since this is not an area of writing in which I work.

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Regulatory Writing

Regulatory writing is a specific branch of medical writing, and as is often the case with other aspects of medical writing, it can be a difficult one to break into. Companies don’t typically want to hire writers without regulatory experience, yet at the same time, it’s tough to get the experience when nobody will hire you!

Recently, however, I came across an interesting thread on LinkedIn that I forwarded to Paul. It was in the group Medical Writers’ Forum”, and was started by Ellen Barosse, CEO of Synchrogenix, a large international regulatory writing firm.

She specifically discussed the problem of how many people want to be regulatory writers but they don’t know where to start.

One problem that she highlighted, however, is that frequently when she interviews candidates, she is surprised at how few actually set themselves up to increase the chances of being hired in the first place. She says that in order to maximize your chances of being hired, be sure to follow these basic points:

  • Understand what’s involved: You must like science, have good mathematics skills, know how to write well, and be able to sit at a computer for at least 8 hours each day. But you also need to be social enough to interact with colleagues and clients.
  • Have good computer skills: You need to be an expert in Windows (make sure you can efficiently manage files and folders, and that you know how to control where your documents end up when you save them) Word (make sure you know how to apply styles to paragraphs, and can paste from different source without corrupting the styles; that you can switch between portrait and landscape pages, insert cross-references, and handle a table of contents; that you have the necessary skills to make complex tables) and Excel (know how to use built-in functions such as sum, average, standard deviation) – practice makes perfect, so make sure you can work swiftly and correctly. And use a PC – Macs are not often used in the regulatory field.
  • Develop an understanding of language fundamentals and style-guide conventions: Know when to use commas, hyphens, and other punctuation. Study the AMA Manual of Style (in particular Sections 2,3, and 4) – most pharmaceutical companies have adopted modifications of this as their writing style.
  • Develop excellent proofreading and editing skills: Find proofreading and quality-control tests online. Regulatory writers often have to do quality control as part of their work, so you should practice these online tests over and over until you can catch every error.
  • Learn how to write well: Many writers swear by Strunk & White’s “The Elements of Style”. Practice writing for at least one hour each day. Get other writers to critique your work. Take as many opportunities as possible to write – for your local church or community group, local newspaper – any chance you can take! Write simply and clearly.

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Ellen Barosse concluded these suggestions by noting how these can all be followed without much expense – online resources can be utilized, and don’t forget your local library for books. Pursuing as many of these options as possible will only further increase your chances of being hired, and will leave you better prepared to learn regulatory writing – when you are hired, you’ll be able to concentrate on learning the content of the profession rather than beginning to learn to use Windows and Excel effectively, etc., or learn AMA writing style.

Barosse mentioned that her company, Synchrogenix, has a new program to train a small number of inexperienced regulatory writers – they offer this program their in Nashville & Austin offices here in the US, and in Manchester, England too. 

So the future for writers wanting break into the regulatory field may be opening up! Be sure to check out these options if you’re looking to get into the regulatory writing field.

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And Finally……

Another writer also left a comment on the thread, adding that anyone who wants to get into regulatory writing needs to produce a CV that is well-structured and correctly formatted – otherwise it’s unlikely that anyone will trust you with regulatory documents.

He noted that it’s also important for writers to know what they are getting into in this particular field of writing. Regulatory writing is not just about medical writing – but also about looking for relevant patterns in data, and recognizing what is important. So if you don’t enjoy statistics and data evaluation, or complex tables, the regulatory writing field may not be the career for you.

He reminded everyone of how important it is to have some awareness of the regulatory aspects of the pharmaceutical industry – simply having qualifications such as a medical degree or a PhD are not necessarily going to immediately qualify you for this branch of writing. Guidelines differ across different areas, such as veterinary products, human pharmaceuticals, and the medical device industry. They also differ across different geographical locations. So another piece of advice that he offers when applying for a job, is to be aware of what the specific company does – check what products it has, and the regulatory environment in which it operates.

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I thought this was all great advice for budding regulatory writers, so in addition to forwarding the link to Paul who had originally emailed me, I decided to share it here for anyone looking to break into this field.

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Image credit jannoon028@FreeDigitalPhotosl